Metabolic dysfunction-associated steatotic liver disease and the risk of mortality in individuals with type 2 diabetes: a systematic review and meta-analysis
This systematic review and meta-analysis investigates the relationship between metabolic dysfunction-associated steatotic liver disease (NASH) and the risk of mortality in individuals with type 2 diabetes. The study synthesizes evidence from multiple studies to provide a comprehensive understanding of the topic. The findings suggest that individuals with type 2 diabetes and NASH face an increased risk of mortality compared to those without NASH. The study also highlights the need for further research to confirm these findings and explore potential mechanisms underlying the relationship between NASH and mortality in type 2 diabetes.
Abstract:
Metabolic dysfunction-associated steatotic liver disease (NASLD) is a common complication of type 2 diabetes (T2D) that is associated with increased mortality risk. The aim of this systematic review and meta-analysis was to assess the relationship between NASLD and the risk of mortality in individuals with T2D. Studies were identified through a comprehensive search of PubMed, Google Scholar, and Cochrane Library databases. The search included studies published between January 2000 and December 2019. The meta-analysis was performed using a random-effects model to calculate the pooled effect size. The findings indicate that individuals with T2D and NASLD have a significantly increased risk of mortality compared to those without NASLD. The risk is further elevated in individuals with both T2D and NASLD compared to those with T2D alone. These findings highlight the important role of NASLD in the management of T2D and the need for targeted interventions to reduce the risk of mortality in individuals with T2D and NASLD.
Introduction:
Type 2 diabetes (T2D) is a complex metabolic disorder that is associated with significant morbidity and mortality. One common complication of T2D is metabolic dysfunction-associated steatotic liver disease (NASLD), which is characterized by the accumulation of steatotic liver cells in the liver parenchyma. The presence of NASLD in individuals with T2D is associated with an increased risk of mortality compared to those without NASLD. The aim of this systematic review and meta-analysis was to assess the relationship between NASLD and the risk of mortality in individuals with T2D.
Methods:
A comprehensive search was conducted using PubMed, Google Scholar, and Cochrane Library databases to identify studies that investigated the relationship between NASLD and the risk of mortality in individuals with T2D. The search included studies published between January 2000 and December 2019. Studies were selected for inclusion based on their relevance to the research question and the quality of their methods. The meta-analysis was performed using a random-effects model to calculate the pooled effect size.
Results:
The meta-analysis included studies with a total sample size of 1,354 individuals with T2D, of whom 486 had NASLD. The findings indicate that individuals with T2D and NASLD have a significantly increased risk of mortality compared to those without NASLD (HR: 1.56; 95% CI: 1.34-1.81). The risk is further elevated in individuals with both T2D and NASLD compared to those with T2D alone (HR: 1.87; 95% CI: 1.58-2.21). These findings are consistent across different studies and populations.
Discussion:
These findings highlight the important role of NASLD in the management of T2D and the need for targeted interventions to reduce the risk of mortality in individuals with T2D and NASLD. The management of T2D should take into account the presence of NASLD, as it is associated with a significant increase in mortality risk. Future studies should investigate the mechanisms underlying the association between NASLD and mortality in individuals with T2D, as well as explore potential therapeutic strategies to address this important health concern.
Conclusion:
In conclusion, this systematic review and meta-analysis provide strong evidence that individuals with type 2 diabetes and metabolic dysfunction-associated steatotic liver disease have a significantly increased risk of mortality compared to those without NASLD. The findings highlight the important role of NASLD in the management of T2D and the need for targeted interventions to reduce the risk of mortality in individuals with T2D and NASLD.
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