Metabolic dysfunction-associated steatotic liver disease and the risk of mortality in individuals with type 2 diabetes: a systematic review and meta-analysis
This systematic review and meta-analysis investigate the relationship between metabolic dysfunction-associated steatotic liver disease (NASH) and the risk of mortality in individuals with type 2 diabetes. The studies reviewed suggest that the presence of NASH increases the mortality risk in individuals with type 2 diabetes, with the magnitude of the risk varying depending on the severity of liver disease and the presence of other comorbidities. The findings highlight the importance of assessing liver disease in individuals with type 2 diabetes and the potential benefits of managing it to reduce mortality risk.
Background: Type 2 diabetes is a major public health concern, and the risk of mortality in individuals with type 2 diabetes is high. Metabolic dysfunction-associated steatotic liver disease (NASLD) is one of the complications of type 2 diabetes, and its relationship with the risk of mortality in individuals with type 2 diabetes has been extensively studied. However, the results of these studies are inconsistent, and a systematic review and meta-analysis are needed to clarify the relationship between NASLD and the risk of mortality in individuals with type 2 diabetes.
Objectives: The objectives of this systematic review and meta-analysis are to assess the relationship between NASLD and the risk of mortality in individuals with type 2 diabetes and to evaluate the impact of NASLD on the prognosis of individuals with type 2 diabetes.
Methods: We will conduct a systematic review of the literature to identify all relevant studies that have examined the relationship between NASLD and the risk of mortality in individuals with type 2 diabetes. We will then perform a meta-analysis to pool the results of these studies and calculate an overall effect size. The quality of the studies will be assessed using established criteria, and a sensitivity analysis will be conducted to explore the impact of study quality on the results.
Results: The results of this systematic review and meta-analysis will provide a comprehensive understanding of the relationship between NASLD and the risk of mortality in individuals with type 2 diabetes. The findings will help to clarify whether NASLD is associated with an increased risk of mortality in individuals with type 2 diabetes and, if so, to what extent. The results will also evaluate the impact of NASLD on the prognosis of individuals with type 2 diabetes.
Conclusion: This systematic review and meta-analysis will provide important insights into the relationship between NASLD and the risk of mortality in individuals with type 2 diabetes, which will help to inform clinical decision-making and public health strategies. By understanding the role of NASLD in the mortality risk of individuals with type 2 diabetes, we can develop better interventions to improve their prognosis.
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